Timing of high-efficacy therapy in relapsing-remitting multiple sclerosis: A systematic review

B Merkel; H Butzkueven; AL Traboulsee; E Havrdova; T Kalincik

Journal article

Timing of high-efficacy therapy in relapsing-remitting multiple sclerosis: A systematic review

B Merkel, H Butzkueven, AL Traboulsee, E Havrdova, T Kalincik

Autoimmunity Reviews | Published : 2017

DOI: 10.1016/j.autrev.2017.04.010

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Abstract

Background Immunotherapy initiated early after first presentation of relapsing-remitting multiple sclerosis is associated with improved long-term outcomes. One can therefore speculate that early initiation of highly effective immunotherapies, with an average efficacy that is superior to the typical first-line therapies, could further improve relapse and disability outcomes. However, the most common treatment strategy is to commence first-line therapies, followed by treatment escalation in patients who continue to experience on-treatment disease activity. While this monitoring approach is logical, the current lack of effective regenerative or remyelinating therapies behoves us to consider hig..

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University of Melbourne Researchers

Tomas Kalincik Author

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Awarded by Multiple Sclerosis Society

Funding Acknowledgements

This work was comissioned by the Multiple Sclerosis Society (UK) [programme award nr. 46]. The authors have received funding from National Health and Medical Research Council [project grants 1083539, 1032484 and 1129189, practitioner fellowship 1080518, and centre for research excellence 1001216], University of Melbourne [Faculty of Medicine, Dentistry and Health Sciences research fellowship] and the Czech Ministry of Education [project grant PRVOUK-P26/LF1/4].